For Business-to-Business Use Only  |  These statements have not been evaluated by the FDA  |  Not intended to diagnose, treat, cure, or prevent any disease
Supplement Science

Iso Compliant Ashwagandha Active Peptide Production

ISO-compliant manufacturing systems provide the documented quality management framework required for premium retail and international market access. Ashwagandha (Withania somnifera), the crown jewel of Ayurvedic adaptogens, has accumulated one of the most robust clinical evidence bases of any herbal ingredient, with KSM-66® — the high-concentration root extract standardized to >=3% withanolide content — emerging as the gold-standard form for human clinical trials. The withanolide class of compounds activates the GABAergic system, inhibits the HPA axis (cortisol-producing stress pathway), and modulates the serotonin and dopamine neurotransmitter systems. The landmark 2019 study demonstrated that KSM-66® ashwagandha (600 mg/day for 8 weeks) reduced perceived stress scores (PSS-10) by 44% and cortisol levels by 27.9% compared to placebo. Beyond stress, trials show benefits for testosterone support (+17% vs placebo), exercise performance (+21% upper body strength), and sleep quality.

NUCOREBIO OEM / ODM ADAPTOGEN POWER 600 mg · 60 Caps GMP NON-GMO VEGAN NET WT. 54g

Label design for illustration. Custom branding, label copy, and packaging are adapted per client brief under full white-label OEM service.

Market Signal
GOOGLE SEARCH INTEREST
Global, 2019–2025
LIVE DATA EST.
0 25 50 75 100 2019 2020 2021 2022 2023 2024 2025 100 ↑ Supplement RCT published
Source: Google Trends normalized index (0–100), worldwide, search term . Estimated trajectory based on publicly reported data and NuCoreBio market analysis. For indicative purposes.
Manufacturing Services

OEM & ODM Advantages

01
Pharmaceutical-Grade Ingredient

≥98% purity, COA, MSDS available. Flexible MOQ.

02
Custom Formulation

In-house scientists for proprietary blends, IP protection.

03
Dosage Forms

Capsules, softgels, tablets, sachets – small to high volume.

Why Partner with NuCoreBio?
Full-service contract manufacturing
✓
Vertically Integrated — supply chain control
✓
Science-Backed — advanced R&D team
✓
Low MOQ & Scalable — 500 units entry
✓
Multi-Market Compliance — FDA, EFSA, TGA
ISO 22000GMPHalalKosher
FAQ

Frequently Asked Questions

NuCoreBio performs batch-level HPLC testing for active ingredient identity and potency, ICP-MS for heavy metals (lead, arsenic, mercury, cadmium), microbiological screening (total plate count, yeast/mold, E. coli, Salmonella), and residual solvent testing where applicable. All testing is conducted by ISO 17025-accredited third-party laboratories with COA documentation per production batch.
For stress and cortisol reduction: 300–600 mg/day of KSM-66® standardized extract. For sleep and anxiety: 600 mg 1–2 hours before bed. Long-term studies show sustained benefits without tolerance development.
Multiple RCTs show that ashwagandha supplementation (600 mg/day KSM-66®) increases testosterone by 14–17% compared to placebo in resistance-trained males over 8 weeks, alongside increases in LH and DHEA-S.
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Regulatory Notice: B2B ingredient sourcing only. Statements not evaluated by FDA/EFSA. Finished product compliance is brand responsibility.

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